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Pivotal studies to support the effective-ness were performed in patients with underlying amyo-trophic lateral sclerosis (ALS) or multiple sclerosis (MS).The typical starting dose is one capsule daily by mouthfor 7 days after which 1 capsule is used every 12 hours iftolerated. Demonstrate thefinger-to-nose test to assess accuracy ofmovements, then ask the client to extendand hold arms out to the side with eyesopen. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, LeliasJM, Dumont X, Ferrara P, McKeon F, Caput D (1997) Monoallelically expressed gene relatedto p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

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